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Updated: Jun 23, 2026

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
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Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

Real-World Effectiveness of Biologic and Targeted Synthetic Therapies in Rheumatoid Arthritis: a Multicenter Study

Hani M Almoallim1, Sami M Bahlas2, Yasser Bawazir3

  • 1Department of Internal Medicine, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.

Open Access Rheumatology : Research and Reviews
|June 22, 2026
PubMed
Summary
This summary is machine-generated.

This study found that advanced rheumatoid arthritis (RA) therapies, including biologic (bDMARDs) and targeted synthetic DMARDs (tsDMARDs), showed comparable effectiveness and persistence in Saudi patients. Treatment outcomes were similar across agents, emphasizing standardized care.

Keywords:
antirheumatic agentsarthritisbiological productsjanus kinase inhibitorspatient compliancerheumatoidtreatment outcome

Related Experiment Videos

Last Updated: Jun 23, 2026

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
04:50

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

Area of Science:

  • Rheumatology
  • Immunology
  • Pharmacology

Background:

  • Rheumatoid arthritis (RA) management follows treat-to-target strategies, escalating therapy from conventional synthetic DMARDs (csDMARDs) to advanced options like biologic (bDMARDs) or targeted synthetic DMARDs (tsDMARDs) if remission or low disease activity is not achieved.
  • Real-world comparative effectiveness data for these advanced therapies are limited in certain populations.

Purpose of the Study:

  • To compare 12-month outcomes and treatment persistence among biologic (bDMARDs) and targeted synthetic DMARDs (tsDMARDs) in Saudi patients with RA.
  • To evaluate the effectiveness of advanced RA therapies within the Rheumatoid Arthritis Saudi Database (RASD).

Main Methods:

  • A prospective, multicenter cohort study of 647 RA patients in the RASD receiving bDMARDs or tsDMARDs.
  • 12-month follow-up with assessments of disease activity (DAS28-CRP), function (HAQ), fatigue, and remission.
  • Statistical analyses included mixed-effects models, regression analyses, and Kaplan-Meier methods to compare outcomes and treatment persistence.

Main Results:

  • Significant disease activity improvement (DAS28-CRP) over time across all advanced RA therapies (p<0.0001).
  • No significant differences in 12-month disease activity, function, fatigue, or remission rates between different bDMARDs and tsDMARDs, with overlapping confidence intervals.
  • Low discontinuation rates and no significant differences in treatment persistence through 36 months (log-rank p=0.17). An isolated worse HAQ score was noted for certolizumab compared to tofacitinib.

Conclusions:

  • Advanced RA therapies demonstrate comparable effectiveness and treatment persistence in Saudi patients.
  • The study highlights the importance of standardized treat-to-target implementation, as evidenced by significant center-level variation in remission rates.
  • Minimal adjusted differences were observed between agents, with a note on certolizumab versus tofacitinib regarding HAQ scores.