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Amoxicillin Direct Oral Challenge in Hospitalized Patients With High-Risk Allergic Reactions, in a
Bryan Le1, Shyam Joshi2, Kendall Tucker1
1Department of Pharmacy Practice, Oregon State University College of Pharmacy, Portland, Oregon, USA.
Abstract:
In 169 hospitalized adults with penicillin allergy histories, either through interview or listed in the electronic medical record of urticaria, angioedema, anaphylaxis, and/or shortness of breath at least 10 years ago, 94.1% tolerated a direct oral amoxicillin challenge led by a non-allergy specialist and were delabeled. Mild reactions occurred in 5.9%, with no severe events. This safe, effective approach may improve antibiotic stewardship, reduce costs, and support broader implementation over penicillin skin testing.
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