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Related Experiment Video

Updated: Jun 23, 2026

Multiple-mouse Neuroanatomical Magnetic Resonance Imaging
09:08

Multiple-mouse Neuroanatomical Magnetic Resonance Imaging

Published on: February 27, 2011

Coordinated Representational Drift Across the Mouse Cortex.

Suhasa Kodandaramaiah, Ryan Peters, James Hope

    Research Square
    |June 22, 2026
    PubMed
    Summary
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    Neural representations drift over time, but this change is coordinated across the mouse dorsal cortex. This coordinated drift preserves spatial map geometry despite individual neuron tuning changes.

    Area of Science:

    • Neuroscience
    • Systems Neuroscience
    • Computational Neuroscience

    Background:

    • Cortical neurons exhibit dynamic spatial tuning, but coordination of this representational drift across brain regions is poorly understood.
    • Understanding network-level coordination is crucial for deciphering how the brain maintains stable representations despite continuous neural changes.

    Purpose of the Study:

    • To investigate the coordination of representational drift across distributed cortical areas.
    • To determine if spatial map geometry is preserved during neural representational drift.

    Main Methods:

    • Chronic widefield calcium imaging with cellular resolution in mice over 47 days.
    • Tracking over 110,000 neurons across retrosplenial, visual, somatosensory, and motor cortices.
    • Analyzing population activity, functional coupling, and representational drift dynamics.

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    Main Results:

    • Spatial tuning showed a posterior-to-anterior gradient, with highest tuning in retrosplenial and visual cortices.
    • All four cortical regions exhibited coordinated representational drift with similar decorrelation timescales.
    • Drift preserved the geometric structure of spatial representations, consistent with an orthogonal transformation of the population code.

    Conclusions:

    • Representational drift is coordinated across the dorsal cortex, not independent.
    • The brain maintains a stable spatial map geometry despite continuous changes in single-neuron tuning.
    • This coordinated drift mechanism ensures the robustness of spatial representations during learning and experience.