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Updated: Jun 23, 2026

4D Imaging of Protein Aggregation in Live Cells
08:59

4D Imaging of Protein Aggregation in Live Cells

Published on: April 5, 2013

Tightly Knotted Enzymes Inhibit Protein-Protein Aggregation

Susmita Sarkar, Hemanth Mandya Nagaiah, Michael L Klein

    Biorxiv : the Preprint Server for Biology
    |June 22, 2026
    PubMed
    Summary

    Protein backbone topology significantly impacts neurodegenerative disease risk. Intact protein knots suppress liquid-liquid phase separation (LLPS), while destabilized knots promote aggregation, linking topological stability to disease mechanisms.

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