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Updated: Jun 24, 2026
11:28
Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus
Published on: October 7, 2011
NAD+ metabolism at the host-virus interface.
Prince Jhandai1,2, Kishore Vaddadi1,2, Lin Liu1,2
1Oklahoma Center for Respiratory and Infectious Diseases, Oklahoma State University, Stillwater, OK, USA.
The Journal of General Virology
|June 22, 2026
Summary
Nicotinamide adenine dinucleotide (NAD+) is vital for cellular functions. Viruses disrupt NAD+ metabolism, impacting replication and persistence, suggesting metabolic resilience as a broad-spectrum antiviral strategy.
Area of Science:
- Biochemistry
- Virology
- Metabolic pathways
Background:
- Nicotinamide adenine dinucleotide (NAD+) is a crucial coenzyme for cellular energy production, DNA repair, and immune signaling.
- Viral infections significantly impact NAD+ metabolism, influencing pathogen replication and persistence.
Purpose of the Study:
- To review the current understanding of NAD+ metabolism and its regulatory enzymes.
- To discuss the intricate relationship between NAD+ homeostasis and viral infections.
Main Methods:
- Literature review of NAD+ metabolism and viral interactions.
- Analysis of NAD+-consuming enzymes like sirtuins, PARPs, and CD38/CD157.
- Examination of how viruses manipulate NAD+ biosynthesis and consumption.
Main Results:
- Viruses actively alter NAD+ levels to promote their survival and replication.
- Key enzymes regulating NAD+ are targets for viral manipulation.
- Disruption of NAD+ homeostasis is a common viral strategy.
Conclusions:
- Understanding viral manipulation of NAD+ metabolism is key to developing novel antiviral therapies.
- Targeting metabolic resilience offers a potential broad-spectrum antiviral approach.
- Further research into NAD+ pathways could uncover new therapeutic targets.
Keywords:
CD38coronavirusinfluenza A virusnicotinamide adenine dinucleotide (NAD+) metabolismpoly (ADP-ribose) polymerases (PARPs)sirtuinsMore Related Videos
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