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Related Experiment Video

Updated: Jun 24, 2026

Percutaneous Hepatic Perfusion (PHP) with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver

Percutaneous Hepatic Perfusion (PHP) with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver

Published on: July 31, 2016

Palliative Therapy for Liver and Biliary Neoplasms.

Bridget N Fahy¹, Matthew C Hernandez²

¹Division of Surgical Oncology, City of Hope National Medical Center, Department of Surgery, 1500 E Duarte Road, Duarte, CA 91010, USA.

Hematology/Oncology Clinics of North America

|June 22, 2026

Summary

This summary is machine-generated.

Managing symptoms from liver and biliary tumors, including pain, jaundice, and ascites, requires integrated palliative strategies. These advanced treatments aim to significantly improve patients' quality of life.

Keywords:

Biliary obstruction Hepatic encephalopathy MA Palliative care Symptom management

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Area of Science:

Hepatology
Oncology
Palliative Care

Background:

Liver and biliary tumors present significant symptom burden.
Common symptoms include pain, jaundice, pruritus, hepatic encephalopathy, bleeding, and ascites.

Purpose of the Study:

To review and integrate state-of-the-art palliative strategies for liver and biliary tumors.
To improve the quality of life for patients with these malignancies.

Main Methods:

Multimodal pain management (procedural and pharmacologic).
Biliary drainage and medications for jaundice and pruritus.
Ammonia reduction for hepatic encephalopathy (lactulose, shunt modification).
Endoscopic and embolization procedures for bleeding.
Distinguishing causes of ascites for targeted interventions.

Main Results:

Effective management of pain, jaundice, pruritus, encephalopathy, bleeding, and ascites is achievable.
Integration of these strategies leads to improved patient outcomes.

Conclusions:

Comprehensive palliative care is essential for liver and biliary tumors.
State-of-the-art interventions significantly enhance patient quality of life.