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  1. Home
  3. Surgical Considerations For Primary Liver Neoplasms.
  1. Home
  3. Surgical Considerations For Primary Liver Neoplasms.

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Laparoscopic Anatomical Liver Segment VII Resection with Liver Parenchymal Transection Following a Priority Approach
13:57

Laparoscopic Anatomical Liver Segment VII Resection with Liver Parenchymal Transection Following a Priority Approach

Published on: May 23, 2025

Surgical Considerations for Primary Liver Neoplasms.

Dillon C Cheung1, Chee-Chee Stucky2

  • 1Department of Surgery, Mayo Clinic Arizona, Phoenix, AZ, USA.

Hematology/Oncology Clinics of North America
|June 17, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

Primary liver cancers like hepatocellular carcinoma and intrahepatic cholangiocarcinoma have poor survival rates. Surgical resection offers the best prognosis, with advanced therapies aiding resectability in select cases.

Keywords:
Future liver remnantHepatic artery infusion chemotherapyHepatocellular carcinomaIntrahepatic cholangiocarcinomaLiver resectionMinimally invasive surgeryNeoadjuvant therapyPortal vein embolization

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Area of Science:

  • Hepatobiliary surgery
  • Surgical oncology
  • Gastroenterology

Background:

  • Primary liver neoplasms, including hepatocellular carcinoma and intrahepatic cholangiocarcinoma, represent a significant global health challenge.
  • These cancers are associated with poor survival outcomes and limited effective systemic treatment options.
  • Accurate preoperative assessment is crucial for determining surgical candidacy.

Purpose of the Study:

  • To outline the essential components of preoperative assessment for liver neoplasms.
  • To discuss the role of surgical resection and minimally invasive techniques.
  • To explore strategies for managing advanced but potentially resectable liver tumors.

Main Methods:

  • Comprehensive preoperative evaluation including advanced imaging, liver function tests, and future liver remnant (FLR) volumetry.
  • Surgical resection aiming for negative margins.
  • Application of minimally invasive surgical approaches in selected patients.
  • Neoadjuvant therapies such as chemotherapy, portal vein embolization (PVE), radiation lobectomy, and hepatic artery infusion chemotherapy (HAIC) for downstaging.

Main Results:

  • Surgical resection with clear margins provides the best opportunity for long-term survival in primary liver neoplasms.
  • Minimally invasive surgical techniques are increasingly utilized for eligible patients, potentially reducing morbidity.
  • Neoadjuvant strategies can facilitate tumor downstaging, converting initially unresectable disease into a resectable state.

Conclusions:

  • Effective management of primary liver neoplasms necessitates a multidisciplinary approach integrating accurate preoperative assessment and tailored treatment strategies.
  • Surgical resection remains the cornerstone of curative treatment, with advancements in surgical techniques and neoadjuvant therapies expanding resectability.
  • Further research into systemic therapies and innovative downstaging techniques is warranted to improve outcomes for patients with advanced liver cancer.