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Updated: Jun 24, 2026
07:10
High-Throughput Expression and Purification of Human Solute Carriers for Structural and Biochemical Studies
Published on: September 29, 2023
Drug transporters in drug disposition - highlights from the year 2025
Philip Sandoval1, Pallabi Mitra2, Masanori Nakakariya3
1Takeda Development Center Americas, Inc. (TDCA), Lexington, MA, USA.
Drug Metabolism Reviews
|June 23, 2026
Summary
This review highlights key advances in drug transporter sciences, focusing on mechanistic understanding, translational applications, and drug development. It covers new models, biomarkers, and structural insights for better drug disposition prediction.
Area of Science:
- Drug transporter sciences
- Pharmacokinetics and drug metabolism
- Regulatory science
Background:
- Drug transporters significantly impact drug absorption, distribution, and elimination.
- Understanding transporter roles is crucial for effective new drug development.
- Previous reviews have established a precedent for highlighting impactful research.
Purpose of the Study:
- To review and synthesize impactful articles in drug transporter sciences from 2025.
- To highlight advances in mechanistic understanding, translational applications, and drug development.
- To provide perspective on emerging trends shaping the field of transporter sciences.
Main Methods:
- Selection of peer-reviewed articles based on scientific impact, novelty, and relevance.
- Categorization of selected articles into sections: transporter function, in vivo models, biomarkers, and structure/regulation.
- Synopsis and commentary on the significance of individual studies and broader trends.
Main Results:
- Integration of mechanistic approaches like physiologically based pharmacokinetic (PBPK) modeling for drug-drug interaction evaluation.
- Development of improved in vivo models enhancing translational predictivity.
- Progress in identifying and qualifying endogenous biomarkers for clinical use.
- Advancements in structural biology bridging molecular understanding with clinical outcomes.
Conclusions:
- Collective advances indicate a shift towards integrated and predictive frameworks for assessing drug disposition.
- These developments have significant implications for drug development and regulatory science.
- The review offers a curated overview of critical progress in the field.
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