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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
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Related Experiment Video

Updated: Jun 24, 2026

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
09:37

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

Published on: July 14, 2016

Subtype-Specific Associations Between Hyperlipidemia and Age-Related Cataract: A Clinic-Based Cross-Sectional Study.

Yepei Qin1,2,3, Yingying Hong1,2,3, Li Ning1,2,3

  • 1Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, People's Republic of China.

Clinical Interventions in Aging
|June 23, 2026
PubMed
Summary

Hyperlipidemia is linked to age-related cataract (ARC) severity, especially posterior subcapsular cataract (PSC). Elevated triglycerides and apolipoprotein B are risk factors, while HDL-C shows an inverse association, suggesting lipid biomarkers for ARC risk stratification.

Keywords:
LOCS IIIcataractdyslipidemiaslipoproteinstriglycerides

Related Experiment Videos

Last Updated: Jun 24, 2026

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
09:37

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

Published on: July 14, 2016

Area of Science:

  • Ophthalmology
  • Metabolic Research
  • Gerontology

Background:

  • Age-related cataract (ARC) is a primary cause of blindness in the elderly.
  • Metabolic imbalances are implicated in lens epithelial cell dysfunction and ARC.
  • The specific link between hyperlipidemia and ARC subtypes remains debated.

Purpose of the Study:

  • To investigate the association between hyperlipidemia and the severity of different age-related cataract subtypes.
  • To identify specific lipid biomarkers related to ARC pathogenesis.

Main Methods:

  • A cross-sectional study included 384 ARC patients stratified by cataract morphology (cortical, nuclear, PSC).
  • Ocular and systemic evaluations were conducted.
  • Multivariate logistic regression analyzed associations between serum biochemical indices and ARC severity.

Main Results:

  • Hyperlipidemia was independently associated with posterior subcapsular cataract (PSC) severity.
  • Elevated apolipoprotein B (APO-B) and triglycerides (TG) were risk factors for PSC.
  • High-density lipoprotein cholesterol (HDL-C) showed an inverse association with PSC severity.

Conclusions:

  • Findings indicate a subtype-specific link between hyperlipidemia and ARC, particularly PSC.
  • Lipid biomarkers like APO-B, TG, and HDL-C may inform future ARC risk stratification and prevention strategies.