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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Therapeutic Drug Monitoring: Overview and Classification01:16

Therapeutic Drug Monitoring: Overview and Classification

Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood at designated intervals to ensure the drug concentration stays within a therapeutic range. This monitoring is crucial for optimizing individual dosage regimens, enhancing therapeutic efficacy, and minimizing drug-related toxicity. TDM is vital for drugs with narrow therapeutic windows, significant variability in pharmacokinetics, and a clear correlation between plasma levels and...

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Related Experiment Video

Updated: Jun 24, 2026

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
08:19

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo

Published on: July 20, 2019

Nano-Immunotherapy Targeting TAMs: Precisely Regulating TAMs to Reverse Immunosuppressive TME.

Jin-Ming Zhang1, Chun-Ling Dong2, Bo Li1

  • 1Department of Oral Anatomy and Physiology, Jilin Provincial Key Laboratory of Oral Biomedical Engineering, Hospital of Stomatology, Jilin University, Changchun, People's Republic of China.

International Journal of Nanomedicine
|June 23, 2026
PubMed
Summary
This summary is machine-generated.

Nano-immunotherapy targeting tumor-associated macrophages (TAMs) offers a promising strategy to reverse the immunosuppressive tumor microenvironment (TME) and combat cancer. Innovations in nanocarriers enhance drug delivery and therapeutic precision for improved anti-tumor outcomes.

Keywords:
cancerimmunotherapynanocarriertargetingtumor-associated macrophages

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Inducing Targeted Mild Hyperthermia in Murine Tumor Models through Photothermal Conversion of Near-infrared Light by Intratumoral Gold Nanorods

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Last Updated: Jun 24, 2026

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Published on: October 10, 2025

Area of Science:

  • Oncology and Immunology
  • Nanotechnology and Drug Delivery

Background:

  • Tumor-associated macrophages (TAMs) play a critical role in cancer development and immune suppression within the tumor microenvironment (TME).
  • Targeting TAMs via nano-immunotherapy is a key strategy to overcome immunosuppression and inhibit cancer progression.

Purpose of the Study:

  • To review recent advances in nano-immunotherapy strategies targeting TAMs.
  • To explore challenges and knowledge gaps in TAM-targeted nano-immunotherapy.
  • To highlight innovations in nanocarrier design for enhanced drug delivery and biocompatibility.

Main Methods:

  • Review of nano-immunotherapeutic strategies including TAM reprogramming, polarization modulation, mediator regulation, exhaustion induction, phagocytosis enhancement, metabolism modulation, recruitment inhibition, and PD-L1 blockade.
  • Exploration of nanocarrier designs: inorganic nanocrystals, organic polymers, hybrid systems, biodegradable polymers, and biomimetic vesicles.
  • Focus on cell surface receptors and downstream signaling pathways relevant to TAM targeting.

Main Results:

  • Nano-drug delivery systems are evolving into multimodal platforms with synergistic drug action and physical energy interventions.
  • Intelligent nanocarriers, including nanorobots, offer autonomous diagnostic and therapeutic capabilities for precise anti-tumor strategies.
  • Various strategies effectively target TAMs to remodel the TME and inhibit cancer.

Conclusions:

  • TAM-targeted nano-immunotherapy holds significant potential for cancer treatment by remodeling the TME.
  • Innovations in nanocarrier design are crucial for improving targeting precision, biocompatibility, and therapeutic efficacy.
  • Intelligent nanorobots represent a future direction for highly precise and autonomous cancer therapy.