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Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
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STAT3 and Its Targeting Inhibitors in Oral Squamous Cell Carcinoma.

Mingjing Jiang1,2, Bo Li1,2

  • 1Jilin Provincial Key Laboratory of Oral Biomedical Engineering, Department of Oral Anatomy and Physiology, Hospital of Stomatology, Jilin University, Changchun 130021, China.

Cells
|October 14, 2022
PubMed
Summary

Signal transducer and activator of transcription 3 (STAT3) drives oral squamous cell carcinoma (OSCC) progression. Targeting STAT3 with small molecule inhibitors shows promise for developing new OSCC treatments.

Keywords:
STAT3oncogeneoral squamous cell carcinomasmall molecule inhibitors

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Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Oral squamous cell carcinoma (OSCC) accounts for 90% of oral cancers, with a poor 5-year survival rate of 50%.
  • Current OSCC therapies are insufficient, necessitating novel therapeutic strategies.
  • The signal transducer and activator of transcription 3 (STAT3) pathway is implicated in OSCC development and progression.

Purpose of the Study:

  • To review the oncogenic role of STAT3 in oral squamous cell carcinoma.
  • To emphasize therapeutic strategies and small molecule inhibitors targeting STAT3.
  • To propose future research directions for developing specific STAT3 inhibitors for OSCC.

Main Methods:

  • Literature review focusing on the role of STAT3 in OSCC.
  • Analysis of STAT3's downstream target genes and their functions in cancer.
  • Evaluation of existing and potential STAT3 inhibitors for OSCC treatment.

Main Results:

  • STAT3 is overexpressed and constitutively active in OSCC, promoting proliferation, anti-apoptosis, migration, invasion, angiogenesis, and immune escape.
  • STAT3 regulates cancer stem cell self-renewal and differentiation.
  • STAT3 signaling pathway inhibitors demonstrate significant anticancer effects in preclinical studies.

Conclusions:

  • STAT3 is a critical oncogenic driver in OSCC.
  • Targeting STAT3 represents a promising therapeutic strategy for OSCC.
  • Further development of specific STAT3 inhibitors is crucial for advancing OSCC treatment.