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A highly selective near-infrared fluorescent probe for imaging peroxynitrite in the brains of epileptic mice
Yuqing Hu1, Qiu-Lian Hao2, Xiaohang Wang1
1School of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang, Jiangsu, 212100, China. 2621993143@qq.com.
Abstract:
A ratiometric near-infrared probe, CCy7-DP, was developed for peroxynitrite detection, utilizing a highly selective addition-elimination reaction between ONOO- and diphenyl phosphinate. This reaction triggered an electron rearrangement of the cyanine skeleton and a blue shift in fluorescence, enabling high-contrast imaging of peroxynitrite in the brains of epileptic mice.
