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A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
Published on: June 4, 2017
Allergic Sensitization to Common Ragweed and Mugwort Pollen Allergens: A 6-Year Single-Center Retrospective Analysis
Zhipeng Zhao1, Runqing Li1, Rui Li1
1Department of Laboratory Medicine, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing, China, tsinghua.edu.cn.
Journal of Immunology Research
|June 23, 2026
Summary
This study tracked specific immunoglobulin E (sIgE) responses to common ragweed and mugwort pollen allergens over six years. Mugwort pollen showed stronger allergenicity, with higher sensitization rates observed in males and younger individuals, indicating potential cross-reactivity.
Area of Science:
- Allergy and Immunology
- Environmental Health
- Epidemiology
Background:
- Common ragweed and mugwort are prevalent aeroallergens contributing to allergic respiratory diseases.
- Understanding sensitization trends to these allergens is crucial for public health management.
- Longitudinal data on specific immunoglobulin E (sIgE) responses provides insights into allergenicity and population susceptibility.
Purpose of the Study:
- To analyze sensitization trends to common ragweed and mugwort pollen allergens over a six-year period.
- To identify demographic factors influencing sensitization rates, including age and gender.
- To compare the allergenicity and cross-reactivity patterns of common ragweed and mugwort.
Main Methods:
- Retrospective analysis of 2798 patient records with common ragweed and mugwort pollen-sIgE testing (2020-2025).
- Exploration of sensitization characteristics across different time periods, age groups, and genders.
- Comparative analysis of sensitization profiles and IgE detection levels.
Main Results:
- Positive rates for both allergens decreased from 2020-2024, with a rebound in 2025.
- The 6-15 years age group showed the highest positive rates, decreasing with age.
- Males exhibited significantly higher sensitization rates than females for both allergens.
Conclusions:
- A rebound in common ragweed and mugwort pollen-sIgE positive rates was observed in 2025.
- Sensitization rates decreased with age and were higher in males.
- Mugwort pollen demonstrated stronger allergenicity, with high consistency and cross-reactivity observed between the two allergens.
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