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Updated: Jun 24, 2026

08:07
Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
Published on: September 6, 2017
Identification of the HLA-A*30:262 Allele in a Brazilian Individual by Next-Generation Sequencing
Emerson Fernando Garcia Machado1,2, Josiane Aparecida Linhares1, Maria Eduarda Dugonski1
1Laboratory of Immunogenetics, Cajuru University Hospital, Curitiba, Parana, Brazil.
HLA
|June 23, 2026
Abstract:
HLA-A*30:262 differs from HLA-A*30:01:01:01 by a non-synonymous substitution in exon 4.
Related Concept Videos
Next-generation Sequencing
The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.
Genome-wide Association Studies-GWAS
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...

