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Updated: Jun 24, 2026
10:26
Inducing Apical Periodontitis in Mice
Published on: August 6, 2019
Could Trained Immunity Impact Periapical Healing? A Biological Perspective
Mohammed Turky1,2, Paul R Cooper3
1Department of Endodontics, Faculty of Dentistry, Minia University, Minia, Egypt.
International Endodontic Journal
|June 23, 2026
Summary
Trained immunity, a form of innate immune memory, may explain varied healing after root canal treatment. This immune priming influences periapical tissue repair and bone regeneration, offering a new perspective beyond infection control.
Area of Science:
- Immunology
- Endodontics
- Regenerative Medicine
Background:
- Periapical healing after root canal treatment shows significant variability despite consistent microbial control.
- Trained immunity, involving epigenetic and metabolic reprogramming of innate immune cells, offers a novel explanation for this variability.
- Previous inflammatory exposures may prime periapical tissues, altering healing responses.
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