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Related Experiment Video

Updated: Jun 25, 2026

Intramyocardial Transplantation of MSC-Loading Injectable Hydrogels after Myocardial Infarction in a Murine Model
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Intramyocardial Transplantation of MSC-Loading Injectable Hydrogels after Myocardial Infarction in a Murine Model

Published on: September 20, 2020

Micropeptide-Inspired Engineered Stapled Peptide-Loaded Hydrogel Platform Promotes Skeletal Muscle Repair After

Surojit Ghosh1, Mohammad Umar Arshi2, Satyajit Ghosh2

  • 1Smart Healthcare Department, Interdisciplinary Research Platform, Indian Institute of Technology, Jodhpur, Rajasthan 342030, India.

ACS Applied Bio Materials
|June 23, 2026
PubMed
Summary

A novel stapled peptide, M.R., promotes skeletal muscle regeneration by enhancing differentiation, reducing inflammation, and limiting fibrosis. Encapsulated in a hydrogel, M.R. offers a promising therapeutic for severe muscle injuries.

Keywords:
hydrogelmuscle injurymuscle repairmyogenesispeptide-based therapeutics

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Published on: June 14, 2015

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Last Updated: Jun 25, 2026

Intramyocardial Transplantation of MSC-Loading Injectable Hydrogels after Myocardial Infarction in a Murine Model
09:19

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Published on: September 20, 2020

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A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.
06:15

A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.

Published on: June 14, 2015

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Materials Science

Background:

  • Severe skeletal muscle injuries often lead to incomplete functional recovery.
  • Persistent inflammation and fibrosis hinder muscle regeneration.
  • Current therapies (anti-inflammatories, stem cells, growth factors) show limited success.

Purpose of the Study:

  • To develop a novel peptide therapeutic for enhanced skeletal muscle repair.
  • To investigate the efficacy of a stapled peptide (M.R.) in promoting muscle regeneration.
  • To create a biocompatible hydrogel platform for sustained delivery of M.R.

Main Methods:

  • Development of a micropeptide-inspired stapled peptide (M.R.).
  • Encapsulation of M.R. within a borax-functionalized guar gum hydrogel.
  • Evaluation of M.R. efficacy in a cryolesion-induced muscle injury model.

Main Results:

  • M.R. demonstrated potent regenerative capacity at nanomolar concentrations.
  • M.R. promoted myogenic differentiation, modulated inflammation, and limited fibrosis.
  • The hydrogel platform enabled sustained release and enhanced muscle repair.

Conclusions:

  • M.R. represents a first-in-class peptide therapeutic for muscle regeneration.
  • The hydrogel delivery system provides a biocompatible platform for M.R.
  • This multidimensional approach offers a promising strategy for treating severe muscle injuries.