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Updated: Jun 25, 2026

A Spheroid Killing Assay by CAR T Cells
Published on: December 12, 2018
The three-dimensional perspective of CAR-T cell therapy in autoimmune diseases
Jiayi Shen1, Jianhua Mao2, Qing Ye3
1Department of Nephrology, Children's Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, 310052, China.
Abstract:
Chimeric antigen receptor T (CAR-T) cell therapy has achieved remarkable success in haematological malignancies, ushering in the era of adoptive cell therapy. In recent years, CAR-T cell therapy has been progressively explored in autoimmune diseases (AIDs), with the goal of inducing deep immune remodelling and durable drug-free remission in selected patients. This review evaluates CAR-T cell therapy in AIDs through three clinically relevant dimensions: depth, breadth, and length. We use this framework to discuss therapeutic efficacy, immune remodelling mechanisms, disease spectra, target selection, long-term persistence and safety, with the aim of supporting more precise and controllable clinical development.
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