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Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis
Published on: March 9, 2018
Surgery for Pulmonary Aspergillosis
José de Sá Moraes Neto1, André Nathan Costa2, Brendon M Stiles3
1Department of Thoracic Surgery, Instituo do Coracao, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, São Paulo, Brazil.
Abstract:
Chronic pulmonary aspergillosis encompasses a spectrum of progressive lung diseases that commonly arise in patients with prior structural lung damage. This article outlines current diagnostic criteria, highlights distinctions between aspergilloma and chronic cavitary forms, and summarizes the roles of medical therapy and surgery. Surgical resection remains the gold standard for symptomatic aspergilloma and selected cases of localized, treatment-refractory disease, with low mortality but notable morbidity. Nonsurgical options such as bronchial artery embolization and intracavitary antifungal therapy are valuable for high-risk patients. Multidisciplinary evaluation is essential to optimize outcomes and reduce disease-related morbidity.
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