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Improvement of pattern electroretinogram parameters following glaucoma surgery
Emmanuel Bettach1, Leandro Oliverio2, Kaweh Mansouri3,4
1Swiss Visio Glaucoma Research Center, Montchoisi Clinic, Lausanne, Switzerland. manou.bettach@gmail.com.
International Ophthalmology
|June 23, 2026
Summary
Glaucoma surgery significantly improves Pattern Electroretinogram (PERG) parameters in patients with successful intraocular pressure (IOP) reduction. This suggests enhanced retinal ganglion cell function after surgery.
Area of Science:
- Ophthalmology
- Neuroscience
Background:
- Glaucoma is a leading cause of irreversible blindness.
- Glaucomatous optic neuropathy affects retinal ganglion cells.
- Pattern Electroretinogram (PERG) assesses retinal ganglion cell function.
Purpose of the Study:
- To evaluate changes in PERG parameters after glaucoma surgery.
- To correlate PERG dynamics with intraocular pressure (IOP) reduction.
Main Methods:
- Retrospective analysis of 23 eyes from 21 glaucoma patients.
- Pre- and post-operative PERG assessments (Mag, MagD, MagD/Mag ratio).
- Comparison of PERG parameters in eyes with successful IOP reduction.
Main Results:
- All PERG parameters showed significant improvement post-surgery (p < 0.05).
- Average Mag increased from 0.97 to 1.36 μV.
- Eyes without IOP reduction showed no PERG improvement.
Conclusions:
- Successful glaucoma surgery positively impacts retinal ganglion cell function.
- Enhanced PERG parameters indicate improved cellular activity post-IOP reduction.
- PERG serves as a valuable tool to monitor surgical outcomes in glaucoma.
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