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Updated: Jun 25, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
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Published on: January 19, 2016

Isothiourea-Catalyzed Atroposelective O-Boc Protection for the Kinetic Resolution of NOBINs

Zhe Xu1, Hongwei Zhou2, Xingkuan Chen3

  • 1School of Chemistry and Chemical Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, P. R. China.

Organic Letters
|June 24, 2026
PubMed
Summary

This study introduces a novel isothiourea-catalyzed method for the kinetic resolution of 2-amino-2′-hydroxy-1,1′-binaphthyls (NOBINs) via O-Boc protection, offering a new route for enantioselective synthesis.

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