Approach to the Patient with Low-Risk Thyroid Cancer

The 2025 American Thyroid Association (ATA) Management Guidelines for Adult Patients with Differentiated Thyroid Cancer focus on the care of patients with low to high-risk disease with management recommendations reflecting the evolving evidence in the field. Most patients diagnosed with differentiated thyroid cancer have low-risk disease. For the care of patients with low-risk disease, the new clinical guidelines emphasize shared decision making, de-escalating care in patients who are recurrence free, and long-term survivorship care. We present three cases of patients with diagnoses of low-risk differentiated thyroid cancer to illustrate management options and key considerations.