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Mini-Review: Allicin as a Potential Neuroprotective Compound in Neurological Disorders.

Wen-Rui Tang¹, Ke Qian Chen²

¹Department of Infection Control, Xiangtan Central Hospital (The Affiliated Hospital of Hunan University), Xiangtan, 411100, People's Republic of China.

Neuropsychiatric Disease and Treatment

|June 24, 2026

Summary

This summary is machine-generated.

Allicin shows promise for neuroprotection against various brain injuries by reducing inflammation and oxidative stress. Further clinical trials and improved delivery systems are needed for its application in neurological diseases.

Keywords:

Alzheimer’s disease Parkinson’s disease allicin brain injury neurological diseases

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Experimental Models to Study the Neuroprotection of Acidic Postconditioning Against Cerebral Ischemia

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Area of Science:

Neuroscience
Pharmacology
Natural Products

Background:

Allicin, a compound found in garlic, has garnered significant interest for its potential neuroprotective properties.
Neurological diseases pose a major global health challenge, necessitating the exploration of novel therapeutic agents.

Purpose of the Study:

To review the current research on allicin's role in neuroprotection.
To summarize allicin's extraction, detection, synthesis, toxicity, and delivery systems.
To evaluate allicin's efficacy in various neurological conditions.

Main Methods:

Comprehensive literature review of studies on allicin and neurological diseases.
Analysis of allicin's mechanisms of action, including its effects on oxidative stress, inflammation, and apoptosis.
Evaluation of research progress in drug delivery systems for allicin.

Main Results:

Allicin demonstrates neuroprotective effects in preclinical models of Alzheimer's disease, Parkinson's disease, traumatic brain injury, and stroke.
Mechanisms include inhibition of oxidative stress, neuroinflammation, apoptosis, regulation of mitochondrial function, and improved blood-brain barrier integrity.
Current evidence is primarily from animal studies, with limited high-quality clinical data.

Conclusions:

Allicin exhibits significant potential for treating neurological disorders.
Challenges include allicin's chemical instability and low bioavailability, hindering clinical translation.
Future research should focus on robust clinical trials and advanced delivery systems to enhance allicin's therapeutic application.