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Related Concept Videos

Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.

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Related Experiment Video

Updated: Jun 25, 2026

Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches
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Aptamer-Functionalized Liposome Delivery System Based on Multifunctional Microreactor Design.

Jiaqi Guo1, Wenjin Chen2, Bing Wang3

  • 1Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian 361102, China.

ACS Applied Materials & Interfaces
|June 24, 2026
PubMed
Summary
This summary is machine-generated.

This study introduces an advanced microfluidic chip for creating targeted doxorubicin-loaded liposomes. These novel nanoparticles show improved stability and tumor specificity for effective breast cancer therapy.

Keywords:
breast cancerdrug deliveryfluid dynamics simulationintegrated microfluidicsmultifunctional liposomes

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Oncology

Background:

  • Breast cancer is a leading cause of death in women, with chemotherapy facing challenges due to systemic toxicity and poor drug targeting.
  • Conventional chemotherapy often leads to severe side effects because drugs affect both cancerous and healthy cells.
  • Developing targeted drug delivery systems is crucial to enhance therapeutic efficacy and minimize toxicity.

Purpose of the Study:

  • To develop an integrated microfluidic chip for efficient, one-step postprocessing of liposomes.
  • To create AS1411 aptamer-functionalized liposomes loaded with doxorubicin for targeted breast cancer therapy.
  • To optimize liposome characteristics for improved stability, drug encapsulation, and tumor targeting.

Main Methods:

  • Utilized an integrated microfluidic chip (MMLP) with diverse microchannel designs (Y-shaped, crescent, U-shaped, Tesla) and pillar arrays for enhanced mixing.
  • Employed computational fluid dynamics (CFD) to optimize flow-rate ratios for simultaneous solvent removal and AS1411 aptamer conjugation via thiol-maleimide chemistry.
  • Characterized doxorubicin-loaded AS1411 aptamer-functionalized liposomes (D@Lip-Apt) for size, polydispersity index (PDI), and drug encapsulation efficiency.

Main Results:

  • Achieved uniform liposome size (155 ± 3.2 nm) and high drug encapsulation efficiency (76.64 ± 0.52%).
  • Demonstrated superior nanoparticle stability and enhanced tumor-targeting specificity in vitro and in vivo studies.
  • Validated the microfluidic platform's capability for scalable production through dimensional or parallel amplification.

Conclusions:

  • The developed MMLP platform enables efficient, one-step modification of liposomes for targeted drug delivery.
  • AS1411 aptamer-functionalized doxorubicin liposomes show significant potential for improving breast cancer therapy outcomes.
  • The modular microreactor design offers flexibility and scalability for industrial production of targeted nanotherapeutics.