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Updated: Jun 25, 2026

An Effective Mouse Model of Unilateral Renal Ischemia-Reperfusion Injury
Published on: July 15, 2021
Ivermectin in Acute Renal Injury Induced by Ischemia-Reperfusion: An Experimental Study in Wistar Rats
Raphael Cuencas Budini1, Dulce Aparecida Barbosa1, Iris Gabriela Piazentin de Oliveira1
1Universidade Federal de São Paulo. São Paulo, São Paulo, Brazil.
Objectives:
to assess the effect of ivermectin in an experimental model of ischemia-reperfusion as a risk factor.
Methods:
twenty adult male Wistar rats were randomized into the following groups: Sham: surgical simulation without clamping of the renal pedicles; ischemia: clamping of the renal pedicles for 30 minutes; Sham + ivermectin: 10 mg/kg of ivermectin, orally, once daily for five days; and Ischemia + ivermectin. Physiological parameters such as body weight, water and food intake, renal function (creatinine clearance), and oxidative profile (urinary peroxides and thiobarbituric acid reactive substances) were assessed.
Results:
an increase in kidney-to-body weight ratio, serum creatinine, and oxidative stress was observed in animals treated with ivermectin (p<0.05).
Conclusions:
the use of ivermectin, associated with the ischemia-reperfusion risk factor, demonstrated nephrotoxic action in Wistar rats, evidenced by impaired renal function and increased oxidative stress.
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