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Updated: Jun 25, 2026
05:53
An Effective Mouse Model of Unilateral Renal Ischemia-Reperfusion Injury
Published on: July 15, 2021
Ivermectin in Acute Renal Injury Induced by Ischemia-Reperfusion: An Experimental Study in Wistar Rats
Raphael Cuencas Budini1, Dulce Aparecida Barbosa1, Iris Gabriela Piazentin de Oliveira1
1Universidade Federal de São Paulo. São Paulo, São Paulo, Brazil.
Revista Brasileira De Enfermagem
|June 24, 2026
Summary
Ivermectin administration exacerbated kidney injury in a rat model of renal ischemia-reperfusion. This study found ivermectin increased oxidative stress and impaired renal function in rats subjected to this risk factor.
Area of Science:
- Nephrology
- Pharmacology
- Toxicology
Background:
- Renal ischemia-reperfusion injury is a significant clinical concern.
- Ivermectin is an antiparasitic drug with potential anti-inflammatory properties.
- The impact of ivermectin on renal ischemia-reperfusion injury is not well-established.
Purpose of the Study:
- To evaluate the effects of ivermectin on an experimental model of renal ischemia-reperfusion injury in Wistar rats.
Main Methods:
- Twenty adult male Wistar rats were divided into four groups: Sham, Ischemia, Sham + Ivermectin, and Ischemia + Ivermectin.
- Ivermectin (10 mg/kg) was administered orally for five days.
- Renal function (creatinine clearance) and oxidative stress markers (urinary peroxides, thiobarbituric acid reactive substances) were assessed.
Main Results:
- Ivermectin administration led to an increased kidney-to-body weight ratio.
- Serum creatinine levels were elevated in rats treated with ivermectin.
- Significant increases in oxidative stress markers were observed in the ivermectin groups.
Conclusions:
- Ivermectin demonstrated nephrotoxic effects in the context of renal ischemia-reperfusion.
- Impaired renal function and heightened oxidative stress were key indicators of ivermectin's adverse impact.
- These findings suggest caution when considering ivermectin in patients at risk for or experiencing renal ischemia-reperfusion injury.
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