Related Experiment Videos
Cardiometabolic protective mechanisms and efficacy of sodium-glucose cotransporter 2 inhibitors (SGLT2i) in SLE
Youngmin Kim1, April Jorge1, Brittany N Weber2
1Division of Rheumatology, Inflammation and Immunity, Massachusetts General and Brigham and Women's Hospitals, Harvard Medical School, Boston, MA, USA.
Abstract:
SLE is a chronic autoimmune disease associated with substantial cardiovascular, metabolic and renal morbidity. Sodium-glucose cotransporter 2 inhibitors (SGLT2i), initially developed for type 2 diabetes (T2D), have demonstrated beneficial effects beyond glucose lowering, including improvements in metabolic, cardiovascular and renal outcomes. These effects span multiple domains, including glycaemic control, body weight and blood pressure reduction, heart failure and atherosclerotic cardiovascular disease outcomes, kidney function preservation and potential immunomodulatory pathways. This narrative review summarizes the metabolic, cardiovascular, renal and immunomodulatory effects of SGLT2i relevant to SLE. Evidence from the general population supports cardiometabolic and renal benefits, while observational studies and early-phase trials in SLE and LN suggest potential benefits in selected patients. However, SLE-specific evidence remains limited, and important gaps persist regarding efficacy and safety in active disease. Further studies are needed to define the role of SGLT2i in SLE.
Related Concept Videos
Oral Hypoglycemic Agents: Biguanides and Glitazones
Dipeptidyl Peptidase 4 Inhibitors
Secondary Active Transport
Secondary Active Transport
Oral Hypoglycemic Agents: α-Glucosidase Inhibitors
Acarbose and miglitol are typically...
Glucose Transporters
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes: