Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Integrating nnU-Net Segmentation and Clinical-Radiomics for Multicenter MRI-Based Assessment of Soft Tissue Sarcoma Grade and Ki-67 Expression.

Journal of magnetic resonance imaging : JMRI·2026
Same author

Mechanisms of electroacupuncture for the treatment of Alzheimer's disease by activating Wnt/β-catenin pathway to improve blood-brain barrier function.

IBRO neuroscience reports·2026
Same author

Gut microbiota-dependent metabolism of 6-shogaol generates bioactive metabolites that mediate its anti-inflammatory effects.

Food & function·2026
Same author

Glucose-responsive AMPK-TET2-5hmc oscillation links metabolic stress to circadian transcription and Parkinson's disease relevance.

NPJ Parkinson's disease·2026
Same author

AI-guided analysis of human pancreatic islet sociology reveals distinct cell compositional changes in type 1 diabetes.

bioRxiv : the preprint server for biology·2026
Same author

Application and Future Development of Artificial Saliva in People with Dysphagia.

Journal of agricultural and food chemistry·2026
Same journal

Erratum for the Research Article "Assessing the health risks of rice cadmium content standards in China" by H. Chu <i>et al</i>.

Science advances·2026
Same journal

Erratum for the Research Article "Developmental regulation of Erk signaling by mitotic kinases" by F. Chen <i>et al</i>.

Science advances·2026
Same journal

Magnetically levitated metasurface enabling tangible and bidirectional human-machine interaction.

Science advances·2026
Same journal

A general photoinduced manganese-catalyzed platform for the sequential difunctionalization of [1.1.1]propellane.

Science advances·2026
Same journal

Turning sound and force into light with AlN:Mn<sup>2+</sup> mechanoluminescence.

Science advances·2026
Same journal

Extreme dominance of Earth-origin heavy ions in the intense ring current near the Earth during the May 2024 super geomagnetic storm.

Science advances·2026
See all related articles

Related Experiment Video

Updated: Jun 26, 2026

Studying the Epithelial Effects of Intestinal Inflammation In Vitro on Established Murine Colonoids
06:31

Studying the Epithelial Effects of Intestinal Inflammation In Vitro on Established Murine Colonoids

Published on: June 2, 2023

Inflammatory monocytes constrain YAP-induced cell proliferation.

Serrena Singh1,2, Nareh Tahmasian3, Jia-Jun Liu4

  • 1Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Yale School of Medicine, New Haven, CT 06520, USA.

Science Advances
|June 24, 2026
PubMed
Summary
This summary is machine-generated.

The Hippo pathway coactivators YAP and TAZ have distinct roles. YAP promotes cell dedifferentiation and immune clearance, while TAZ drives organ growth and sustained maintenance, impacting cancer patient survival.

More Related Videos

Conditional Knockdown of Gene Expression in Cancer Cell Lines to Study the Recruitment of Monocytes/Macrophages to the Tumor Microenvironment
10:59

Conditional Knockdown of Gene Expression in Cancer Cell Lines to Study the Recruitment of Monocytes/Macrophages to the Tumor Microenvironment

Published on: November 23, 2017

Related Experiment Videos

Last Updated: Jun 26, 2026

Studying the Epithelial Effects of Intestinal Inflammation In Vitro on Established Murine Colonoids
06:31

Studying the Epithelial Effects of Intestinal Inflammation In Vitro on Established Murine Colonoids

Published on: June 2, 2023

Conditional Knockdown of Gene Expression in Cancer Cell Lines to Study the Recruitment of Monocytes/Macrophages to the Tumor Microenvironment
10:59

Conditional Knockdown of Gene Expression in Cancer Cell Lines to Study the Recruitment of Monocytes/Macrophages to the Tumor Microenvironment

Published on: November 23, 2017

Area of Science:

  • Cell biology
  • Cancer research
  • Immunology

Background:

  • YAP (Yes-associated protein) and TAZ (Transcriptional coactivator with PDZ-binding motif) are key transcriptional coactivators in the Hippo pathway.
  • These proteins regulate cellular growth and organ size.
  • Their distinct structures suggest unique functional roles that warrant investigation.

Purpose of the Study:

  • To investigate the independent functional differences between YAP and TAZ.
  • To analyze the long-term behavior of YAP- and TAZ-predominant clones in the liver.
  • To explore the impact of YAP and TAZ on immune responses and disease outcomes.

Main Methods:

  • Generation of YAP- and TAZ-predominant cell clones in a liver model.
  • Long-term observation of clonal behavior and organ growth.
  • Analysis of immune cell recruitment and inflammatory environment.
  • Correlation of YAP/TAZ expression with patient survival data in colorectal cancer and hepatocellular carcinoma.

Main Results:

  • YAP clones induced rapid cell dedifferentiation and inflammatory immune cell recruitment, leading to clearance.
  • TAZ clones promoted an anti-inflammatory environment, resulting in sustained organ growth and increased mortality.
  • Inhibition of inflammatory monocytes allowed YAP clonal growth.
  • High YAP expression correlated with better 5-year survival in colorectal cancer patients, while high TAZ expression correlated with poor survival.

Conclusions:

  • YAP and TAZ exhibit distinct biological functions with significant implications for organ homeostasis and disease.
  • YAP's pro-inflammatory role contrasts with TAZ's pro-growth and anti-inflammatory effects.
  • Understanding these intrinsic differences is crucial for developing targeted therapies in YAP/TAZ-driven diseases like cancer.