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Published on: August 16, 2018
Thianthrenium Salts Enable Regio- and Stereoselective C(sp2)-H Arylation of Enamides with Simple Arenes
Ruo-Nan Cao1, Meng-Wei Sheng1, Meng-Ting Chu1
1College of Advanced Interdisciplinary Science and Technology, Henan University of Technology, Zhengzhou 450001, China.
Abstract:
We report a palladium(II)-catalyzed regio- and stereoselective β-C(sp2)-H arylation of enamides with simple arenes under base- and ligand-free conditions via thianthrenium salts, affording a broad array of geometrically defined β-arylated enamides with an exquisite Z configuration. This transformation is characterized by operational simplicity, readily available and bench-stable aryl surrogates, broad substrate scope, and extraordinary compatibility with diverse functionalities. The utility of this approach has been demonstrated by the late-stage diversification of biologically active molecules.
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