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Molecular insights into Pterygium: The emerging role of microRNAs in pathogenesis and therapeutic potential

Abdulrahman Alamri1

  • 1Department of Ophthalmology, King Khalid University, Abha, Saudi Arabia.

Tissue & Cell
|June 24, 2026
PubMed
Abstract

Insights

This study identifies key microRNAs (miRNAs) and molecular pathways, including the miR-200 family, involved in pterygium development. Understanding these mechanisms offers potential for new preventive strategies and therapies for this common eye condition.

Area of Science:

  • Ophthalmology
  • Molecular Biology
  • Genetics

Background:

  • Pterygium is a prevalent ocular surface disorder in tropical regions, causing visual impairment and discomfort.
  • Understanding the molecular basis of pterygium is essential for effective treatment and reducing recurrence.

Purpose of the Study:

  • To identify critical microRNAs (miRNAs) implicated in pterygium pathogenesis.
  • To elucidate the molecular pathways driving pterygium formation and progression.

Main Methods:

  • Comprehensive analysis of scientific databases and literature.
  • Investigation of miRNA functions in pterygium onset, progression, and therapeutic potential.

Main Results:

  • The miR-200 family and other miRNAs are linked to pterygium development and severity.
  • Associated mechanisms include cell proliferation, apoptosis, IL-17 signaling, IGFBP-2, and epithelial-mesenchymal transition (EMT).

Conclusions:

  • Elucidating molecular pathways offers targets for pterygium prevention and treatment.
  • Further research is needed to validate findings for clinical application.
Keywords:
Conjunctival diseasesEpithelial-mesenchymal transitionPterygiummiRNA

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