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Updated: Jun 26, 2026

Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice
Published on: September 19, 2016
BCG enables protection against malaria through adjuvanting an adenovirus-vectored vaccine
Sören Reinke1, Marta Ulaszewska1,2, Qi Su3
1The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Abstract:
BCG vaccination against TB may also reduce malaria incidence through non-specific innate immune activation. We investigated whether giving BCG alongside an adenoviral-vectored malaria vaccine improves protection against malaria in mice. Co-immunisation broadened and strengthened the early innate cytokine responses, enabling strong CD8+ T cell-dependent protection. Our findings suggest co-immunisation with BCG and adenoviral vector as a promising strategy to combat both TB and malaria in double-endemic regions.
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