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Published on: November 14, 2025
Mammographic Microcalcifications and Breast Cancer: A Case - Control Study
Muhammad Usman Sami1, Maira Saeed1, Sadia Nazeem2
1Department of Ophthalmology, Rehman Medical Institute, Peshawar, Pakistan.
Asian Pacific Journal of Cancer Prevention : APJCP
|June 25, 2026
Summary
Mammographic microcalcifications are strong indicators of breast cancer risk, especially in postmenopausal women. Early detection through mammography aids in risk stratification and diagnosis.
Area of Science:
- Radiology
- Oncology
- Medical Imaging
Background:
- Microcalcifications are early indicators of potential breast malignancy on mammography.
- Their precise association with breast cancer risk requires further investigation.
Purpose of the Study:
- To examine the link between mammographic microcalcifications and breast cancer risk.
- To evaluate the predictive value of microcalcifications in diagnostic mammography.
Main Methods:
- A case-control study involving 300 women aged 30+ undergoing diagnostic mammography.
- 150 patients with confirmed breast cancer and 150 matched controls.
- Multivariable logistic regression analyzed microcalcifications, considering age, menopausal status, and ACR breast density.
Main Results:
- Microcalcifications were significantly more prevalent in breast cancer patients (50.7%) than controls (20.7%).
- Microcalcifications showed an independent association with breast cancer (adjusted OR 5.51).
- Perimenopausal women had the highest breast cancer odds (adjusted OR 14.30).
Conclusions:
- Mammographic microcalcifications are potent independent predictors of breast cancer.
- Their value is particularly notable in peri- and postmenopausal women for risk assessment.
- These findings underscore the clinical importance of microcalcifications in mammographic evaluations.
