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Related Experiment Video

Updated: Jun 26, 2026

Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion

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Published on: April 11, 2018

Multiscale Modeling and Analysis of Muscle Tissue: A Finite Element Approach for 3D Braided Composite Structures.

Vivek Kumar Dhimole¹, Niraj Kumar^2,3, Seul-Yi Lee³

¹School of Computer Science and Artificial Intelligence, SR University, Warangal 506371, Telangana, India.

Biomimetics (Basel, Switzerland)

|June 25, 2026

Summary

This summary is machine-generated.

This study developed a multiscale finite element model to simulate skeletal muscle mechanics, linking microstructure to whole-muscle behavior. The framework accurately predicts passive muscle elasticity, offering a basis for future active contraction and patient-specific models.

Keywords:

biomechanics computational mechanics multiscale modeling muscles stretch

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Area of Science:

Biomechanics
Computational Modeling
Materials Science

Background:

Skeletal muscle mechanics involve complex fiber-matrix interactions across multiple length scales.
Existing models often lack computational efficiency or fail to capture microstructural load-transfer mechanisms.

Purpose of the Study:

To develop a computationally efficient multiscale finite element framework for skeletal muscle mechanics.
To link muscle microstructure (fibers, endomysium) to whole-muscle behavior (fascicles, epimysium).
To provide a benchmark for future modeling of active contraction and patient-specific conditions.

Main Methods:

A composite-inspired multiscale finite element framework using explicit periodic numerical homogenization.
Microscale resolution of muscle fibers and endomysium.
Mesoscale homogenization for fascicles and macroscale incorporation into a 3D muscle model.

Main Results:

The framework enables scalable 3D simulations while preserving microstructural load-transfer.
Predicted stress-strain relationships for passive elasticity showed excellent agreement (1-3% difference) with experimental data.
The model serves as a foundation for simulating active contraction and viscoelasticity.

Conclusions:

The proposed multiscale framework accurately simulates passive skeletal muscle elasticity.
This approach offers a computationally efficient alternative to existing models.
The framework provides a basis for advanced modeling, including patient-specific studies and active muscle dynamics.