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Published on: June 17, 2014
Bioinspired 3D Printing of Lignocellulose-Based Multimaterial Composites for Extracellular Matrix-Mimicking
Youjin Seol1,2, Myoung Joon Jeon1,2, Sayan Deb Dutta1,3
1Department of Biosystems Engineering, Kangwon National University, Chuncheon-si 24341, Gangwon-do, Republic of Korea.
Biomimetics (Basel, Switzerland)
|June 25, 2026
Summary
Lignocellulose-based multimaterial 3D bioprinting offers a novel approach to create complex, ECM-mimicking scaffolds for enhanced wound healing. These bioinks provide superior mechanical properties and support tissue regeneration.
Area of Science:
- Biomaterials Science
- Biofabrication
- Tissue Engineering
Background:
- The native skin extracellular matrix (ECM) is complex and heterogeneous, posing challenges for replication with single-material hydrogels.
- Multimaterial 3D bioprinting allows for spatial integration of diverse biomaterials, overcoming limitations of conventional methods.
Purpose of the Study:
- To review the use of lignocellulose-based multimaterial printing for creating ECM-mimicking architectures.
- To discuss the roles of cellulose, hemicellulose, and lignin in printability, scaffold properties, and wound healing.
- To present a framework for designing lignocellulose-based bioinks for advanced wound healing applications.
Main Methods:
- Comprehensive literature review on lignocellulose-based multimaterial bioprinting.
- Analysis of studies demonstrating lignocellulose bioinks for scaffold fabrication.
- Discussion of material properties, printability, and biological performance.
Main Results:
- Lignocellulose-based multimaterial bioinks can create porous, ECM-mimicking scaffolds supporting cell adhesion, proliferation, and tissue regeneration.
- Cellulose nanofibers offer high elastic moduli (>100 GPa), and lignin hydrogels achieve compressive moduli up to 135 kPa, providing mechanical integrity.
- These materials show promise for wound healing applications due to structural and functional advantages.
Conclusions:
- Lignocellulose-based multimaterial bioprinting is a promising strategy for fabricating advanced ECM-mimicking scaffolds.
- Further research is needed to address design considerations and limitations for gradient/adaptive scaffolds and smart wound dressings.
