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Sustainable Curcumin-Loaded Poly(Glyceryl Adipate) Nanoparticles Attenuate Adjuvant-Induced Arthritis: A
Rania H H Ahmed1, Mahmoud E Soliman2,3, Sherif F Hammad4,5
1Biotechnology Program, Faculty of Basic and Applied Science, Egypt-Japan University of Science and Technology, New Borg El-Arab City 21934, Alexandria, Egypt.
Biotech (Basel (Switzerland))
|June 25, 2026
Summary
Polymeric nanoparticles effectively deliver curcumin for treating inflammatory diseases by enhancing its bioavailability. This formulation shows promise for arthritis therapy, demonstrating potent anti-inflammatory effects and excellent biocompatibility.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Pharmacology
Background:
- Curcumin exhibits potent anti-inflammatory properties but has poor aqueous solubility and limited bioavailability, restricting its clinical use.
- Developing biocompatible nanocarriers can improve intra-articular curcumin delivery for inflammatory conditions.
Purpose of the Study:
- To formulate curcumin-loaded poly(glyceryl adipate) nanoparticles for enhanced anti-inflammatory delivery.
- To characterize the physicochemical properties, stability, and cytocompatibility of the curcumin nanoparticles.
- To evaluate the anti-inflammatory potential and molecular interactions of the nanoparticles.
Main Methods:
- Synthesis of poly(glyceryl adipate) nanoparticles via polycondensation.
- Curcumin loading using the nanoprecipitation method.
- Physicochemical characterization (particle size, PDI, zeta potential, EE, TEM, FTIR, DSC, in vitro release).
- Stability assessment (sodium sulfate, long-term storage).
- Cytocompatibility evaluation (MTT assay) and anti-inflammatory effect determination (RT-qPCR).
- Molecular docking against Bruton's tyrosine kinase.
Main Results:
- Optimized nanoparticles: 115.8 ± 10.9 nm size, 0.191 ± 0.038 PDI, -22.9 ± 1.5 mV zeta potential, ~95% encapsulation efficiency.
- Demonstrated good physicochemical properties, stability, and significant anti-inflammatory effects.
- Exhibited no significant cytotoxicity on normal and cancerous cell lines.
- Molecular docking suggested potential interaction with Bruton's tyrosine kinase.
Conclusions:
- Curcumin-loaded poly(glyceryl adipate) nanoparticles represent a promising strategy for intra-articular delivery in inflammatory diseases.
- The developed formulation shows excellent biocompatibility and enhanced anti-inflammatory potential.
- Further in vivo studies are warranted to explore their therapeutic efficacy for arthritis.
