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Published on: January 7, 2022
Amylimycins A-C, New Bacillomycin D Analogs from Marine-Derived Bacillus amyloliquefaciens
Jaeyoun Lee1, Seung Hyun Kim1, Soohyun Um2
1College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon 21983, Republic of Korea.
Abstract:
Marine-derived microorganisms are a rich source of structurally diverse natural products with significant pharmaceutical potential. In this study, three new cyclic lipopeptides, amylimycins A-C (1-3), were isolated from a marine-derived Bacillus amyloliquefaciens strain. The chemical structures of these compounds were elucidated through comprehensive spectroscopic analyses and chiral derivatization using 1-fluoro-2,4-dinitrophenyl-5-alanine amide (FDAA). Amylimycins A-C (1-3) were identified as bacillomycin D analogs belonging to the iturin family, characterized by a cyclic heptapeptide core linked to a β-amino fatty acid moiety. Notably, these compounds featured uncommon branched β-amino fatty acid chains with varied chain lengths, representing a distinctive structural characteristic among bacillomycin D analogs. Amylimycins A-C (1-3) showed moderate antibacterial activity against the Gram-positive bacteria Bacillus subtilis and Staphylococcus epidermidis, while displaying weak to no activity against the Gram-negative strains Escherichia coli and Pseudomonas fluorescens.
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