Related Experiment Video
Updated: Jun 26, 2026
06:16
Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease
Published on: August 9, 2024
Clinically Relevant Discordance Between SCORE2 and REGICOR in Spanish Workers: Implications for Cardiovascular Risk
Manuel Sarmiento Cruz1, Pedro Juan Tárraga López2, Mónica Silu Piña Dabreu3
1Primary Care, Balearic Islands Health Service, 07010 Palma, Spain.
Medical Sciences (Basel, Switzerland)
|June 25, 2026
Summary
The SCORE2 model identifies significantly more Spanish workers as high cardiovascular risk than the REGICOR model, indicating potential under-treatment for cardiovascular disease prevention. Further validation is needed to determine the superior predictive model.
Area of Science:
- Cardiology
- Public Health
- Occupational Medicine
Background:
- Cardiovascular risk prediction models are crucial for primary prevention.
- Significant variability exists between contemporary and traditional risk equations.
- SCORE2 and REGICOR are major cardiovascular risk assessment tools in Spain with methodological differences.
Purpose of the Study:
- To evaluate the agreement between SCORE2 and REGICOR for cardiovascular risk stratification in Spanish workers.
- To quantify cardiovascular risk reclassification with SCORE2 implementation.
Main Methods:
- A multicenter cross-sectional study of 216,310 Spanish workers (aged 40-64) from 2019-2024.
- Cardiovascular risk estimated using SCORE2, REGICOR, ERICE, DORICA, Globorisk, and Framingham equations.
- Agreement assessed using Cohen's kappa and Pearson correlation coefficients.
Main Results:
- SCORE2 identified 7.22% as high risk, compared to 2.04% by REGICOR.
- Minimal agreement between SCORE2 and REGICOR (kappa = 0.094).
- SCORE2 showed higher agreement with Framingham and Globorisk, but low correlation with REGICOR (r = 0.251).
Conclusions:
- Substantial discordance exists between SCORE2 and REGICOR in identifying high cardiovascular risk in Spanish workers.
- Reliance on REGICOR may lead to under-identification of individuals needing primary cardiovascular prevention.
- Prospective outcome-based validation studies are necessary to determine the superior predictive model.
Related Concept Videos
01:30Acute Coronary Syndrome III: Diagnostic Studies
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
01:18Cardiovascular Drugs: Classification based on Therapeutic Indications
Cardiovascular diseases, encompassing a range of conditions, can significantly affect the heart's operations and the overall circulatory system. These conditions impair the heart's ability to pump blood, leading to a deficit in oxygen supply to crucial organs. Anomalies in the heart's electrical system, known as arrhythmias, can cause heartbeats to accelerate or slow down. Usually, heart rates increase during physical activity and decrease while resting or sleeping. However, frequent irregular...
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
01:26Coronary Artery Disease IV: Preventive Measures
Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...