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Uveitis in spondyloarthritis: clinical patterns and differences between axial and peripheral forms
Elena Miguélez Sánchez1, Marina Molinari Pérez2, Carolina Tornero Marín2
1Ramon y Cajal University Hospital, Madrid, Spain. el.misa@hotmail.es.
Clinical Rheumatology
|June 25, 2026
Summary
Acute anterior uveitis is common in spondyloarthritis (SpA). Peripheral SpA subtypes, however, show more chronic, bilateral, and non-anterior uveitis, often needing more immunomodulatory therapy.
Area of Science:
- Ophthalmology
- Rheumatology
- Immunology
Background:
- The link between uveitis and spondyloarthritis (SpA) is known.
- Characterization of uveitis across different SpA types needs further research.
Purpose of the Study:
- To comparatively characterize uveitis across various spondyloarthritis subtypes.
- To identify differences in uveitis presentation and management between axial and peripheral SpA.
Main Methods:
- Retrospective observational study of 163 patients with non-infectious uveitis and SpA.
- Descriptive and comparative analyses were performed across SpA subtypes, axial, and peripheral categories.
Main Results:
- Anterior uveitis (97%) was predominant, with acute relapsing courses (79%).
- Peripheral SpA forms showed higher frequencies of chronic (p < 0.001), bilateral (p < 0.05) uveitis, and intermediate/posterior/panuveitis locations.
- 28.2% required immunomodulatory therapy and 17.8% biologic therapy, with higher biologic discontinuation in peripheral forms (p = 0.059).
Conclusions:
- Acute anterior uveitis is the most frequent pattern in all SpA types.
- Peripheral SpA forms present with more non-anterior, chronic, and bilateral uveitis.
- Peripheral SpA patients may require greater immunomodulatory therapy, necessitating closer monitoring and tailored treatment.
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