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Surgical Retrieval, Isolation and In vitro Expansion of Human Anterior Cruciate Ligament-derived Cells for Tissue Engineering Applications
Published on: April 30, 2014
Editorial Commentary: Different Grafts, Different Problems: Why Anterior Cruciate Ligament Graft Selection Requires
Dylan Luxenburg1, Abid M Khan1, Bruce A Levy1
1Orlando Health Jewett Orthopedic Institute, Orlando, Florida, U.S.A.
Abstract:
Anterior cruciate ligament graft selection requires an individualized approach and shared decision-making based on age, activity level, and numerous other patient- and knee-specific factors. Advantages and disadvantages exist with all graft types. Clinically, many studies have shown similar patient-reported outcomes, return-to-sport, and graft failure rates when comparing bone-patellar tendon-bone and quadriceps tendon grafts. Recently, there has been emerging evidence that quadriceps tendon autografts may offer a donor-site morbidity advantage over bone-patellar tendon-bone grafts while maintaining comparable clinical outcomes. However, the literature has been filled with inconsistencies on how donor-site morbidity is reported. Therefore, further research that explores donor-site morbidity for different graft types using a standardized tool could significantly contribute to optimal graft selection.