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Updated: Jun 27, 2026

Preparation of N-(2-alkoxyvinyl)sulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
Published on: January 3, 2018
Rhodium(III)-Catalyzed Three-Component Oxyamidation of Alkynes with CO2 Retention from Dioxazolones
Shunle Hu1, Lijuan Jv1, Ruijie Mi1
1Institute of Frontier Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Qingdao 266237, China.
Abstract:
Alkyne oxyamidation represents a powerful difunctionalization system toward rapid assembly of tetrasubstituted, electron-rich alkenes. We herein report a Rh(III)-catalyzed three-component oxyamidation protocol utilizing amine, dioxazolone, and indolyl alkyne as substrates. This transformation enables unprecedented utilization of carbon dioxide moiety from dioxazolones─a process that circumvents the stoichiometric CO2 waste typically associated with dioxazolone-mediated nitrene transfer reaction. Operating under mild conditions, the reaction is characterized by 100% atom-economy, high regioregularity, and exclusive Z-selectivity, which allows efficient and sustainable access to densely functionalized tetrasubstituted alkene scaffolds with broad functional group compatibility.
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