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Related Concept Videos

Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview01:19

Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview

In inductively coupled plasma–mass spectrometry (ICP–MS), an inductively coupled plasma (ICP) torch is used as an atomizer and ionizer. Solid samples are dissolved and volatilized before being introduced into the high-temperature argon plasma, while solution samples are nebulized and passed through the high-temperature argon plasma. Plasma dissociates the analytes and ionizes their component atoms to form a mixture of positive ions and molecular species. The positive ions are then passed on to...
Inductively Coupled Plasma Atomic Emission Spectroscopy: Principle01:19

Inductively Coupled Plasma Atomic Emission Spectroscopy: Principle

Inductively coupled plasma (ICP) is the most widely used plasma source in atomic emission spectroscopy (AES), also known as Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES). The ICP source, or torch, consists of three concentric quartz tubes with argon gas flowing through them. A spark from a Tesla coil initiates the ionization of argon, generating a high-temperature plasma.
The ions and electrons produced interact with the fluctuating magnetic field created by a water-cooled...
Atomic Emission Spectroscopy: Lab01:29

Atomic Emission Spectroscopy: Lab

AES is a powerful analytical technique, especially effective when used with plasma sources, producing abundant spectra in characteristic emission lines. The Inductively Coupled Plasma (ICP), in particular, yields superior quantitative analytical data due to its high stability, low noise, low background, and minimal interferences under optimal experimental conditions. However, newer air-operated microwave sources are emerging as promising alternatives that could be more cost-effective than...
Atomic Emission Spectroscopy: Instrumentation01:22

Atomic Emission Spectroscopy: Instrumentation

The instrumentation of atomic emission spectrometry (AES) involves various components, including atomization devices that convert samples into gas-phase atoms and ions. There are two main types of atomization devices: continuous and discrete atomizers.  Continuous atomizers, like plasmas and flames, introduce samples in a constant stream, while discrete atomizers inject individual samples using syringes or autosamplers. The most common discrete atomizer is the electrothermal atomizer.
Mass Spectrometry: Complex Analysis01:21

Mass Spectrometry: Complex Analysis

Mass spectrometry is an important technique for the identification of pure compounds. However, it has some limitations for the analysis of complex mixtures, often due to excessive fragmentation making the spectrum too complicated to decipher. Mass spectrometry can be combined with suitable separation methods in sequence, forming hyphenated methods, which are useful in the analysis of complex mixtures.
GC–MS is a powerful hyphenated method commonly used in forensics and environmental...
Electrospray Ionization (ESI) Mass Spectrometry01:12

Electrospray Ionization (ESI) Mass Spectrometry

Higher molecular weight biomolecules are nonvolatile compounds that may decompose before ionizing or vaporizing during mass analysis with conventional electron impact ionization methods. Accordingly, electrospray ionization (ESI) is the favored method for vaporizing and ionizing biomolecules as it circumvents rapid fragmentation and enables the recording of mass signals for the entire biomolecule.
ESI utilizes electrical energy to transfer ions from the liquid phase of the sample into the...

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Related Experiment Video

Updated: Jun 27, 2026

Analysis of Volatile and Oxidation Sensitive Compounds Using a Cold Inlet System and Electron Impact Mass Spectrometry
05:48

Analysis of Volatile and Oxidation Sensitive Compounds Using a Cold Inlet System and Electron Impact Mass Spectrometry

Published on: September 5, 2014

Single-Particle Isotopic Analysis Using the Liquid Sampling-Atmospheric Pressure Glow Discharge Microplasma Coupled

Suraj Shrestha1, Sarah E Szakas2, Hunter B Andrews3

  • 1Department of Chemistry, Clemson University, Clemson, South Carolina 29634, United States.

Analytical Chemistry
|June 25, 2026
PubMed
Summary
This summary is machine-generated.

This study introduces a novel ultrahigh resolution method for single particle isotopic analysis. The technique uses a liquid sampling-atmospheric pressure glow discharge (LS-APGD) microplasma and Orbitrap mass spectrometry to overcome isobaric interferences in geological and nuclear material analysis.

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Direct Analysis of Single Cells by Mass Spectrometry at Atmospheric Pressure
08:19

Direct Analysis of Single Cells by Mass Spectrometry at Atmospheric Pressure

Published on: September 4, 2010

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Last Updated: Jun 27, 2026

Analysis of Volatile and Oxidation Sensitive Compounds Using a Cold Inlet System and Electron Impact Mass Spectrometry
05:48

Analysis of Volatile and Oxidation Sensitive Compounds Using a Cold Inlet System and Electron Impact Mass Spectrometry

Published on: September 5, 2014

Direct Analysis of Single Cells by Mass Spectrometry at Atmospheric Pressure
08:19

Direct Analysis of Single Cells by Mass Spectrometry at Atmospheric Pressure

Published on: September 4, 2010

Area of Science:

  • Analytical Chemistry
  • Mass Spectrometry
  • Isotope Analysis

Background:

  • Isotope ratio determinations on individual particles offer unique insights compared to bulk measurements.
  • Conventional mass spectrometry struggles with isobaric interferences in complex particle analysis.
  • Single particle (SP) analysis is crucial for detailed sample characterization.

Purpose of the Study:

  • To demonstrate an ultrahigh resolution method for single particle isotopic analysis.
  • To overcome challenges posed by isobaric interferences in particle analysis.
  • To enable accurate isotopic fingerprinting of individual microparticles.

Main Methods:

  • Utilized liquid sampling-atmospheric pressure glow discharge (LS-APGD) microplasma ionization.
  • Coupled LS-APGD with an Orbitrap mass spectrometer and FTMS Booster X2T system.
  • Analyzed well-characterized cerium dioxide (CeO2) microparticles at high mass resolution (~330,000).

Main Results:

  • Achieved accurate 142Ce/140Ce ratio determination for individual microparticles.
  • Demonstrated a detection limit of 2.9 fg for 142Ce.
  • Results showed good agreement with SP inductively coupled plasma time-of-flight mass spectrometry (SP-ICP-TOF-MS).

Conclusions:

  • The developed LS-APGD-Orbitrap method offers ultrahigh resolution for SP isotopic analysis.
  • This technique effectively addresses isobaric interferences in complex samples.
  • The method holds significant potential for geological and nuclear material analysis.