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Failure-to-Rescue From Intraoperative Massive Hemorrhage and Preventable Deaths: A Retrospective Observational Study
Daisuke Koike1, Hiroyuki Kato2, Yoshitomo Kajino3
1Department of Patient Safety, Nagoya University School of Medicine, Nagoya, Aichi, Japan; Department of Gastroenterological Surgery, Fujita Health University School of Medicine, Bantane Hospital, Nagoya, Aichi, Japan; Department of Quality and Safety in Healthcare, Fujita Health University Hospital, Toyoake, Aichi, Japan.
Introduction:
Intraoperative massive hemorrhage (iMH) is a rare but life-threatening surgical event associated with high mortality. Although failure-to-rescue (FTR) is widely used to evaluate surgical quality, FTR during iMH has not been well-characterized. This study aimed to describe clinical patterns of iMH and identify factors associated with FTR.
Methods:
We analyzed that iMH cases reported to Japan's nationwide incident reporting system from 2010 to 2023. The inclusion criteria were cases in which bleeding during noncardiac surgery required a change in surgical approach or was associated with physiological deterioration. iMH was classified into three categories based on hemorrhage controllability: category I, uncontrolled vascular injury; category II, temporarily controllable vascular injury; and category,III progressive, nonfocal bleeding. Univariable and multivariable logistic regression analyses identified factors associated with FTR.
Results:
A total of 353 iMH cases met inclusion criteria, and FTR occurred in 19.3% of cases. Category distribution was 27 (category I), 275 (category II), and 51 (category III), with FTR rates of 59.3%, 9.8%, and 49.0%, respectively (P < 0.001). In multivariable analysis, category II remained strongly protective (odds ratio [OR], 0.09; 95% confidence interval [CI], 0.04-0.23), while non-daytime surgery (OR, 2.64; 95% CI, 1.23-5.67) and greater surgeon experience (per year; OR, 1.04; 95% CI, 1.00-1.08) were independently associated with higher FTR.
Conclusions:
FTR from iMH remains a major clinical challenge. Temporarily controllable hemorrhage showed the lowest FTR, whereas uncontrolled or progressive bleeding carried substantially higher risk. Strengthening timely escalation and intraoperative decision-making may improve rescue performance and reduce preventable deaths.