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Updated: Jun 27, 2026
Fertility Preservation in Patients with Severe Ovarian Dysfunction
Published on: March 25, 2021
In vitro fertilization-frozen embryo transfer in a patient with gonadotroph adenoma: Exacerbation of ovarian
Feifei Lu1, Manlin Xu1, Xiaoyue Shen1
1Center for Reproductive Medicine and Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.
Background:
Functional gonadotropic adenoma is a rare pituitary adenoma. Only a few cases have been reported.
Case Presentation:
Herein, we describe the case of a 30-year-old Chinese woman with functional gonadotroph adenomas (FGAs) with relative hyperprolactinemia and no obvious neurologic signs. Ovarian hyperstimulation due to a follicle-stimulating hormone (FSH)-secreting adenoma was observed after treatment with a gonadotropin-releasing hormone analogue (GnRH-a). The patient was successfully treated through pituitary adenomectomy and experienced a successful pregnancy after in vitro fertilization (IVF).
Conclusion:
Our report suggests that a patient showing ovarian hyperstimulation related to an FSH-secreting adenoma may present with high PRL and estradiol levels and indicates that transsphenoidal surgery should be the first choice for treatment.
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