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In Vivo Morphometric Analysis of Human Cranial Nerves Using Magnetic Resonance Imaging in Menière's Disease Ears and Normal Hearing Ears
Published on: February 21, 2018
Multimodal Audiovestibular Assessment After Intratympanic Gentamicin for Vestibular Drop Attacks in Ménière's
Gabriela Cornelia Musat1, Codrut Sarafoleanu1, Mihai Alexandru Preda1
1Department of Otorhinolaryngology, Faculty of Dentistry, University of Medicine and Pharmacy "Carol Davila", 050474 Bucharest, Romania.
Abstract:
Background and Clinical Significance: Vestibular drop attacks are a rare but disabling manifestation of Ménière's disease. This study aimed to demonstrate the value of multimodal audiovestibular assessment in documenting vestibular deficit after intratympanic gentamicin therapy. Case presentation: A 57-year-old woman with refractory Tumarkin crises underwent serial audiological and vestibular testing before and after intratympanic gentamicin treatment. Post-treatment testing demonstrated right-sided vestibular hypofunction with caloric areflexia, reduced vestibulo-ocular reflex gain, corrective saccades on video head impulse testing, and absent cervical vestibular-evoked myogenic potentials. Hearing thresholds showed transient deterioration with near-baseline recovery during follow-up. Vestibular drop attacks resolved completely. Conclusions: Multimodal audiovestibular assessment provides objective documentation of treatment-induced vestibular hypofunction after intratympanic gentamicin therapy in refractory Ménière's disease.
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