Related Experiment Video
Updated: Jun 27, 2026
07:32
Murine Fecal Isolation and Microbiota Transplantation
Published on: May 26, 2023
Gut Microbiota: Cardiovascular Disease Prevention and Targeted Therapies
Monica Loguercio1, Domenico Mario Giamundo2, Alessia Giglio3
1Cardiovascular Rehabilitation Unit, ASST Crema, Santa Marta Hospital, 26027 Rivolta D'Adda, Italy.
Biomedicines
|June 26, 2026
Summary
The gut microbiota influences cardiovascular health through its metabolites. Targeting the gut microbiome with interventions like diet, probiotics, or FMT offers a novel approach for cardiovascular disease prevention and treatment.
Area of Science:
- Microbiome research
- Cardiovascular disease
- Metabolomics
Background:
- The gut microbiota plays a crucial role in cardiovascular health by modulating metabolic, inflammatory, and vascular pathways.
- Gut dysbiosis is linked to cardiovascular risk factors and disease progression.
- Microbial metabolites (e.g., TMAO, SCFAs) impact lipid metabolism, endothelial function, and inflammation.
Purpose of the Study:
- To review the gut microbiota's role in cardiovascular disease.
- To discuss emerging microbiota-targeted therapeutic strategies.
- To highlight challenges and future directions for clinical translation.
Main Methods:
- Literature review of current evidence on gut microbiota and cardiovascular disease.
- Analysis of multi-omics data linking microbiome-metabolome signatures to cardiovascular risk.
- Critical discussion of various microbiota-targeted interventions.
Main Results:
- Gut dysbiosis is associated with cardiovascular risk factors.
- Microbial metabolites are key mediators in cardiovascular pathways.
- Personalized microbiome-metabolome signatures are emerging for precision medicine.
Conclusions:
- Targeting the gut microbiota offers a novel, complementary strategy for cardiovascular disease prevention and management.
- Dietary interventions, prebiotics, probiotics, synbiotics, and fecal microbiota transplantation show potential.
- Further well-designed clinical studies are needed to overcome challenges in translation to clinical practice.
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