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Updated: Jun 27, 2026

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis

Published on: June 14, 2019

Risk-Based Triage Using Cytology and HPV Genotyping to Reduce Unnecessary Colposcopy: A Real-World Cross-Sectional

Sait Erbey¹, Mehmet Alican Sapmaz¹, Murat Polat¹

¹Department of Obstetrics and Gynecology, Ankara Etlik City Hospital, 06170 Ankara, Turkey.

|June 26, 2026

Summary

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High-grade squamous intraepithelial lesion (HSIL) cytology and HPV16/18 positivity are key indicators for colposcopy. Women with low-grade abnormalities and non-16/18 hrHPV may benefit from surveillance co-testing instead of immediate colposcopy.

Area of Science:

Gynecology
Oncology
Public Health

Background:

HPV testing is standard for cervical cancer screening.
Optimal triage for low-grade abnormalities with non-16/18 high-risk HPV (hrHPV) is debated.
ASCCP risk-based triage strategies aim to refine colposcopy referral.

Purpose of the Study:

Evaluate the impact of ASCCP risk-based triage on colposcopy referral and biopsy outcomes.
Identify predictors of CIN3+ in women undergoing colposcopy.
Assess potential for resource-efficient triage strategies.

Main Methods:

Retrospective cross-sectional study of 2748 women aged 30-65 undergoing colposcopy.
Analysis of cytology, HPV genotypes (16, 18, other hrHPV), and histopathology.

Keywords:

CIN3+HPV genotyping cervical cancer screening co-testing colposcopy human papillomavirus risk-based triage

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Last Updated: Jun 27, 2026

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis

Published on: June 14, 2019

Multivariable logistic regression to identify CIN3+ predictors.

Main Results:

Overall CIN3+ prevalence was 15.9% in the biopsied subgroup (n=1932).
HSIL cytology was the strongest predictor of CIN3+ (aOR 22.41).
HPV16/18 with HSIL/ASC-H cytology showed highest risk; non-16/18 hrHPV with ASC-US/LSIL had <10% CIN3+ rates.

Conclusions:

HSIL cytology and HPV16/18 positivity are primary indications for colposcopy.
Women with ASC-US/LSIL cytology and non-16/18 hrHPV may be candidates for surveillance co-testing.
Risk-based triage could reduce colposcopy utilization, but requires prospective validation.