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Short Interdelivery Interval and Neonatal Acid-Base Status, Postpartum Anemia, and Postnatal Depression: A
Ömer Osman Eroğlu1, Cansın Eroğlu1, Sait Erbey1
1Department of Obstetrics and Gynecology, Ankara Etlik City Hospital, Varlık Mahallesi, Halil Sezai Erkut Caddesi, Yenimahalle, 06170 Ankara, Türkiye.
Journal of Clinical Medicine
|July 15, 2026
Summary
Short interpregnancy intervals (less than 24 months) are linked to postpartum anemia and depression in mothers. This study suggests the connection to depression is not due to anemia, with neonatal outcomes being exploratory.
Area of Science:
- Reproductive Health
- Maternal-Fetal Medicine
- Perinatal Outcomes
Background:
- Short interpregnancy intervals (IDIs) are linked to adverse perinatal outcomes.
- The association between short IDI and neonatal acid-base status, postpartum anemia, and early postnatal depression requires further investigation.
Purpose of the Study:
- To examine the relationship between short interpregnancy intervals (<24 months) and specific maternal and neonatal outcomes.
- Investigate associations with neonatal acid-base status, maternal postpartum anemia, and early postnatal depression.
Main Methods:
- Single-center retrospective cohort study of 851 women with two consecutive singleton births.
- Classification of women based on interpregnancy interval: short (<24 months) vs. standard (≥24 months).
- Multivariable logistic regression and various sensitivity analyses, including IPTW and FDR correction, were employed.
Main Results:
- Short IDI was significantly associated with postpartum anemia (aOR 1.84) and Edinburgh Postnatal Depression Scale scores ≥13 (aOR 1.93) after FDR correction.
- Exploratory analysis indicated a potential association between short IDI and umbilical-artery pH < 7.10 (aOR 2.37), which did not meet FDR significance.
- Postpartum anemia did not mediate the association between short IDI and maternal depression.
Conclusions:
- Short interpregnancy intervals are associated with increased risks of maternal postpartum anemia and early postnatal depression.
- The link between short IDI and depression appears to be independent of hematologic factors like anemia.
- Further multicenter studies are needed to validate these findings, particularly regarding neonatal acid-base status.
