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Related Experiment Video

Updated: Jun 27, 2026

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

Humic Acid Therapy Mitigates Estrogen Deficiency-Induced Alveolar Bone Loss and Modulates the RANKL/OPG Balance.

Larissa Vieira Toledo¹, Maíra Gabrielle de Abreu Ribeiro¹, Thays Cristina Dos Santos¹

¹Faculty of Health Sciences, Universidade Federal de Lavras (UFLA), Lavras 37200-000, Minas Gerais, Brazil.

|June 26, 2026

Summary

This summary is machine-generated.

Humic acids (HAs) show promise in protecting alveolar bone during estrogen deficiency. This study found HAs improved bone mineral content and reduced bone loss in an ovariectomized mouse model.

Keywords:

alveolar bone bone resorption estrogen depletion humic substances natural products

Related Experiment Videos

Last Updated: Jun 27, 2026

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

Area of Science:

Biochemistry
Oral Biology
Pharmacology

Background:

Estrogen deficiency disrupts bone remodeling, negatively impacting alveolar bone.
Humic acids (HAs) possess antioxidant and anti-inflammatory properties, potentially mitigating bone resorption.

Purpose of the Study:

To investigate the effects of HAs on alveolar bone in an experimental model of estrogen depletion.

Main Methods:

Ovariectomized (OVX) and sham-operated mice received daily oral HA or placebo for 28 days.
Mandibles were analyzed for structural, mineral, and histological changes.
Bone elemental composition, alveolar bone loss, RANKL/OPG expression, and osteoclast activity were assessed.

Main Results:

OVX induced bone loss, reduced calcium/phosphorus, increased RANKL, and elevated osteoclast numbers.
HA treatment in OVX mice increased bone mineral content and attenuated alveolar bone loss.
HAs partially increased osteoprotegerin (OPG) and reduced the RANKL/OPG ratio.

Conclusions:

Humic acid therapy attenuated alveolar bone resorption in estrogen-deficient mice.
HA's protective effects may involve modulating the RANKL/OPG balance.