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Interaction Between Chromium Picolinate Supplementation and Strength Training Modifies Cardiomyocyte Relaxation in

Kiany Miranda1, Wagner Muller Estevam2, Daniel Sesana da Silva1

  • 1Postgraduate Program in Physiological Sciences, Health Sciences Center, Federal University of Espírito Santo, Vitória 29047-105, ES, Brazil.

Biomedicines
|June 26, 2026
PubMed
Summary
This summary is machine-generated.

Chromium picolinate supplementation with strength training (ST) did not improve metabolic health in obese rats. The combination therapy may negatively impact cardiomyocyte relaxation, suggesting caution for its use in obesity.

Keywords:
cardiomyocyte relaxationchromium picolinatehigh-fat diet

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Area of Science:

  • Exercise physiology
  • Nutritional biochemistry
  • Cardiovascular research

Background:

  • Obesity is linked to metabolic dysfunction and cardiovascular issues.
  • Chromium picolinate (Cr(pic)3) and strength training (ST) are potential interventions for metabolic health.
  • The combined effects of Cr(pic)3 and ST on cardiac cellular function in obesity are not well understood.

Purpose of the Study:

  • To investigate the impact of Cr(pic)3 supplementation combined with ST on body composition, metabolic parameters, cardiac morphology, and cardiomyocyte function in diet-induced obese rats.
  • To determine if Cr(pic)3 enhances the benefits of ST on metabolic and cardiac health.
  • To assess potential adverse effects of the combined intervention on cardiac cellular function.

Main Methods:

  • Male Wistar rats were fed a high-fat diet to induce obesity.
  • Four groups were established: obese sedentary, obese + ST, obese + Cr(pic)3, and obese + ST + Cr(pic)3.
  • Interventions included 8 weeks of Cr(pic)3 supplementation (80 μg/kg/day) and/or ST (ladder-climbing protocol).
  • Body composition, glucose tolerance, insulin resistance, lipid profiles, cardiac morphology, and cardiomyocyte contractile function were assessed.

Main Results:

  • Neither ST nor Cr(pic)3 alone or combined significantly altered adiposity, glucose tolerance, insulin resistance, or cardiac morphology.
  • Strength training improved maximal load capacity, validating the protocol's efficacy.
  • High-density lipoprotein (HDL) levels were elevated in the combined intervention group compared to obese sedentary rats.
  • While contractile function remained unchanged, the combination of ST and Cr(pic)3 led to prolonged cardiomyocyte relaxation time.

Conclusions:

  • Chromium picolinate supplementation does not appear to enhance the metabolic benefits of strength training in obese rats.
  • The combination of strength training and chromium picolinate may negatively affect cardiomyocyte relaxation dynamics.
  • These findings suggest that chromium picolinate may not be beneficial and could potentially be detrimental to cardiac cellular function in the context of obesity and exercise training.