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Related Concept Videos

Obesity01:24

Obesity

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The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
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Related Experiment Video

Updated: Sep 15, 2025

A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats
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High-Fat Diet Induces MASLD and Adipose Tissue Changes in Obesity-Resistant Rats.

Amanda Rangel Madureira1,2, Vinicius Valois Pereira Martins1, Janete Corrêa Cardoso2

  • 1Postgraduate Program in Nutrition and Health, Health Sciences Center, Department of Integrated Health Education, Federal University of Espírito Santo, Vitória, (Espírito Santo), Brazil.

Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
|July 14, 2025
PubMed
Summary
This summary is machine-generated.

Obesity-resistant rats fed a high-fat diet developed Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), including MASH. Obesity resistance does not prevent diet-induced liver damage.

Keywords:
Obesity Resistance ; Metabolic Dysfunction-Associated Steatotic Liver Disease ; High-Fat-Diet ; Insulin Resistance ; Adipose Tissue

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Area of Science:

  • Metabolic research
  • Hepatology
  • Obesity studies

Background:

  • Obesity resistance (OR) limits weight gain but its impact on metabolic risk, specifically Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), is not fully understood.
  • Investigating MASLD and metabolic parameters in obesity-resistant rats on a high-fat diet (HFD) is crucial for understanding metabolic health.
  • Adipose tissue morphology and MASLD staging are key indicators of metabolic dysfunction.

Purpose of the Study:

  • To investigate MASLD development in obesity-resistant rats.
  • To assess metabolic parameters and adipose tissue morphology in rats fed a high-fat diet.
  • To determine if obesity resistance protects against diet-induced hepatic alterations.

Main Methods:

  • Male Wistar rats were fed standard or high-fat diets for 14 weeks.
  • Animals were classified into control, obesity-prone (OP), and obesity-resistant (OR) groups based on tertiles.
  • Evaluated body weight, adiposity, metabolic markers, liver morphology, and MASLD staging.

Main Results:

  • Obesity-resistant rats had lower body weight, fat pads, and leptin than obesity-prone rats, but higher than controls.
  • MASLD was present in 50% of obesity-resistant rats, with 37.5% progressing to MASH.
  • Obesity-prone rats showed a higher incidence of MASH (87.5%).

Conclusions:

  • Chronic high-fat diet exposure induces metabolic changes and MASLD in obesity-resistant rats.
  • Obesity resistance does not confer protection against high-fat diet-induced liver disease.
  • These findings highlight the importance of diet quality even in metabolically resilient individuals.