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Sensitive Skin Improvement Through Bioinformatics-Identified Cosmetic Ingredients That Regulate Transcriptome-Derived
Seo Hyeong Kim1, Ji Hye Kim1, Ji Min Shin1
1Cutis Biomedical Research Center Co., Ltd., Seoul 07327, Republic of Korea.
Biomolecules
|June 26, 2026
Summary
Researchers developed a new method to find biomarkers for sensitive skin and cosmetic ingredients that can help manage it. This approach led to a successful clinical trial showing improved skin health.
Area of Science:
- Dermatology
- Molecular Biology
- Cosmetic Science
Background:
- Sensitive skin lacks objective diagnostic tools and treatments.
- Current cosmetic development for sensitive skin relies on excluding irritants, not understanding underlying mechanisms.
Purpose of the Study:
- To develop an integrated pipeline for identifying sensitive skin-associated inflammatory biomarkers.
- To discover cosmetic ingredients that regulate these biomarkers.
- To validate the pipeline through in vitro, in vivo, and clinical assessments.
Main Methods:
- Integrated pipeline: microneedle-based skin sampling (MISSM) for transcriptome analysis, bioinformatics, in vitro validation, and clinical assessment.
- Identification and validation of candidate biomarkers (MCOLN1, CYR61, PMAIP1, PTGS2, HMGB2) and cosmetic ingredients.
- Development and pilot clinical trial of a prototype emulsion with longitudinal molecular monitoring via MISSM.
Main Results:
- Sensitive skin biomarkers were significantly upregulated after lactic acid stimulation in cell models.
- In vitro validation confirmed cosmetic ingredients that regulate these biomarkers.
- The prototype emulsion was hypoallergenic and showed significant reduction in target biomarker expression in clinical trials, alongside improved skin hydration, barrier function, redness, and sensory reactivity.
Conclusions:
- The integrated pipeline enables discovery of cosmetic ingredients targeting inflammatory biomarkers in sensitive skin.
- This approach has potential applications for various inflammatory skin conditions.
- MISSM provides a valuable tool for longitudinal molecular monitoring in clinical settings.
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