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Related Concept Videos

Endocarditis III: Medical Management01:18

Endocarditis III: Medical Management

Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
Endocarditis IV: Nursing Management01:29

Endocarditis IV: Nursing Management

Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
Urinary Tract Infection IV: Nursing Management01:17

Urinary Tract Infection IV: Nursing Management

In managing urinary tract infections (UTIs) in nursing, a comprehensive assessment is essential. Begin by gathering subjective data, such as the patient’s complaints of dysuria (painful urination), urinary frequency, urgency, suprapubic pain, and any lower abdominal discomfort. This information can be complemented by questions regarding previous UTIs, sexual activity, and personal hygiene practices, which can provide insight into risk factors. Objective assessment should focus on signs like...
Urinary Tract Calculi VI: Surgical Management01:25

Urinary Tract Calculi VI: Surgical Management

Procedures for Kidney StonesMedical intervention is necessary when kidney stones or renal calculi are too large to pass spontaneously (typically greater than 5 millimeters) when stones are accompanied by symptomatic infection (such as fever or pyelonephritis), when they impair kidney function, or when they cause persistent symptoms like severe pain, nausea, or urinary retention. Additionally, patients with only one kidney or those who cannot be treated with medical management also require...
Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care01:30

Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care

A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...

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Related Experiment Video

Updated: Jun 27, 2026

A Periprosthetic Joint Candida albicans Infection Model in Mouse
04:37

A Periprosthetic Joint Candida albicans Infection Model in Mouse

Published on: February 2, 2024

Management of Periprosthetic Joint Infections: A Multidisciplinary Approach.

Madhan Jeyaraman1,2,3, Filippo Migliorini4,5,6, Luise Schäfer4,5

  • 1Department of Regenerative Medicine, Agathisha Institute of Stem Cell and Regenerative Medicine (AISRM), Chennai 600030, Tamil Nadu, India.

Antibiotics (Basel, Switzerland)
|June 26, 2026
PubMed
Summary
This summary is machine-generated.

Periprosthetic joint infection (PJI) is a severe complication of joint replacement surgery. This review covers PJI

Keywords:
antimicrobial therapyarthroplastybiofilmdiagnosismultidisciplinary managementperiprosthetic joint infectionpreventionrevision surgery

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Novel Diagnostics in Revision Arthroplasty: Implant Sonication and Multiplex Polymerase Chain Reaction

Published on: December 3, 2017

Area of Science:

  • Orthopedics
  • Infectious Diseases
  • Biomaterials Science

Background:

  • Periprosthetic joint infection (PJI) is a major complication of joint arthroplasty, increasing morbidity, mortality, and healthcare costs.
  • The complexity of PJI is due to microbial biofilms, varied clinical signs, and lack of standardized diagnostic criteria.

Purpose of the Study:

  • To provide an integrated overview of PJI pathophysiology, risk factors, and microbiology.
  • To summarize current diagnostic criteria (MSIS/ICM), biomarkers (serology, alpha-defensin), and assays (culture, histology, molecular).
  • To outline medical, surgical, and preventive strategies for PJI management.

Main Methods:

  • Literature review of pathophysiology, risk factors, microbiology, diagnostics, and treatment of PJI.
  • Summary of current diagnostic criteria and emerging biomarkers.
  • Outline of surgical (debridement, revision) and antimicrobial strategies.

Main Results:

  • PJI presents significant clinical and economic challenges.
  • Current diagnostic pathways involve MSIS/ICM criteria, serological markers, synovial biomarkers like alpha-defensin, and various assays.
  • Treatment includes debridement, revision arthroplasty, and targeted antibiotics; prevention strategies are crucial.

Conclusions:

  • Gaps remain in managing antimicrobial resistance, polymicrobial/culture-negative infections, and high-risk patients.
  • Interdisciplinary collaboration and research are vital for refining diagnostics and improving PJI outcomes.
  • Reducing PJI incidence requires continued advancements in prevention and treatment strategies.